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課程名稱 |
高等有機化學專論二
Discussion in Advanced Organic Chemistry (Ⅱ) |
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開課學期 |
110-1 |
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授課對象 |
理學院 化學所化學組 |
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授課教師 |
楊吉水 |
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課號 |
Chem8028 |
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課程識別碼 |
223 D1240 |
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班次 |
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學分 |
4.0 |
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全/半年 |
半年 |
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必/選修 |
必修 |
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上課時間 |
星期一3,4(10:20~12:10)星期五3,4(10:20~12:10) |
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上課地點 |
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備註 |
本課程中文授課,使用英文教科書。上課教室：化210教室
限博士班 且 限本系所學生(含輔系、雙修生)
總人數上限：20人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1101Chem8028_ |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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課程概述 |
I. Essential Concepts for Physical Organic Chemistry (POC) (13 lectures)
II. Representative Reactions that Illustrate the Concepts of POC (11 lectures)
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課程目標 |
I. Essential Concepts for POC (each concept 100 min)
(1) Introduction to POC
(2) Stereochemistry
(3) Conformation
(4) MO and Molecular Modeling
(5) Conjugation and Aromaticity
(6) Non-Covalent Interactions
(7) Reactive Intermediates
(8) Acids and Bases
(9) Reaction Coordinate Diagram (Potential Energy Surface)
(10) Reaction Mechanisms
(11) Linear Free Energy Relationship (Substituent and Solvent Effects)
(12) Kinetic isotope effect
(13) Photochemistry
II. Representative Reactions for illustrating the concepts of POC (each 50 or 100 min)
(1) Nucleophilic Substitution Reactions (SN1, SN2)
(2) Nucleophilic and Electrophilic Aromatic Substitution Reactions (SNAr, SEAr)
(3) Elimination Reaction (E1, E2, and E1cB)
(4) Electrophilic Olefin Addition Reactions
(5) Nucleophilic Carbonyl Addition Reactions
(6) Radical-mediated Reactions
(7) Pericyclic Reaction I : thermal reactions I
(a) Cycloadditions
(b) Electrocyclic Reactions
(8) Pericyclic Reaction II : thermal reactions II
(c) Sigmatropic Rearrangements
(d) Group Transfer Reactions
(9) Pericyclic Reaction III : Photochemical Reactions
(a) The Paterno-Buchi Reaction
(b) Photodimerization of Alkenes
(c) Photochemical Cross-Coupling of Alkenes
(d) Photocycloadditons with Cumulated Double Bonds
(10) Photochemical Reaction: cis-trans photoisomerization
(11) Concluding Remarks |
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課程要求 |
本課程中文授課,使用英文教科書。
限碩博士化學組有機組學生修習.
大學部學生或是他組研究生選修需經教師同意 |
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
1) Anslyn and Dougherty: “Modern Physical Organic Chemistry”2006
Grossman,
2) R. B. “The Art of Writing Reasonable Organic Reaction
Mechanisms” 2nd Ed., 2003.
3) Clayden et al. “Organic Chemistry” 2001.
4) Carey and Sundberg: “Advanced Organic Chemsitry” 5th Ed. 2007
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參考書目 |
1) Anslyn and Dougherty: “Modern Physical Organic Chemistry”2006
2) Grossman, R. B. “The Art of Writing Reasonable Organic Reaction
Mechanisms” 2nd Ed., 2003.
3) Clayden et al. “Organic Chemistry” 2001.
4) Carey and Sundberg: “Advanced Organic Chemsitry” 5th Ed. 2007 |
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評量方式
(僅供參考) |
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No. |
項目 |
百分比 |
說明 |
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1. |
期末考 |
25% |
預計於1月3日(一)舉行 |
2. |
期中考 |
25% |
預計於11月22日(一)舉行 |
3. |
作業成績 |
20% |
共5次，佔學期總成績20% |
4. |
學期報告 |
30% |
規定時間繳交 |
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